And the Democrats might lose their Majority Leader.

"The final nine days of the midterm election are unfolding across a wide landscape, with several dozen House races close enough to break either way, determining whether the election produces a Republican wave that reaches deep into the Democratic ranks. In the Senate, Democrats were bracing to lose seats, but the crucial contests remained highly fluid as Republicans struggled to pull away in several Democratic-leaning states.
[...]
In the House, 28 Democratic seats are either leaning Republican or all but lost to Republican candidates, according to the latest ratings of Congressional races by The New York Times, while 40 seats held by Democrats are seen as tossups. To win a majority, Republicans need to pick up a net of 39 seats; to reach that threshold they will probably have to win at least 44 seats now held by Democrats to offset a handful of projected Democratic victories in Republican-held districts."

NY Times: G.O.P. Is Poised to Seize the House, if Not the Senate, October 23, 2010